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College of Human Sciences

Optimizing Human Performance


Clinical Skeletal Muscle Physiology and Biochemistry Laboratory

About the lab

The Clinical Skeletal Muscle Physiology and Biochemistry Lab is a research facility that is part of the Nutrition, Food & Exercise Sciences Department of the College of Human Sciences at Florida State University in Tallahassee, Florida.

Our lab studies different aspects of muscle physiology and biochemistry in diseased individuals, with a focus on the development of strategies to improve skeletal muscle tissue in the legs of patients suffering from peripheral artery disease (PAD). We evaluate the mechanisms that produce the leg dysfunction of PAD utilizing experimental and computational modeling including cell culture, animal studies and human clinical studies.

Research Interests

Cytoskeletal proteins 

Evaluation and association with muscle morphology


Oxidative stress

Signaling mechanisms in protein modification under ischemia-reperfusion conditions.

Antioxidant defenses


Mitochondrial function ​

Electron transport chain complex activity and ATP production


Calcium protease system

Effects of revascularization operations and supervised exercise treatment

protiens
lab diagram

Our research focuses on the development of improved diagnostic and treatment methods for patients with peripheral artery disease (PAD). PAD affects 8 million people in the USA and is a manifestation of atherosclerosis that produces progressive narrowing and occlusion of the arteries supplying the lower extremities. The most common clinical manifestation of PAD is claudication, i.e., a severe functional limitation identified as gait dysfunction and walking-induced leg muscle pain. A myopathy produced by chronic ischemia is present in the legs of patients with PAD and is central to the functional deterioration seen in claudication.

Faculty / Staff

Panagiotis Koutakis, Ph.D.

Assistant Professor, Lab Director

pkoutakis@fsu.edu
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Eva Papoutsi

Research Assistant

epapoutsi@fsu.edu
4014-B

Students

Ahmed Ismaeel

Ph.D. Student, Exercise Physiology

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Jeremiah Kidd

M.S. Student, Exercise Physiology

Luke Galloway

Undergraduate Student

Katherine Jones

Undergraduate Student

Katie Prezioso

Undergraduate Student

Collaborators

Dr. Ramon Lavado, PhD

Baylor University
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Dr. Jeffrey S. Kirk, MD

Capital Regional Medical Center
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Dr. W. Todd Bohannon, MD

Baylor Scott and White Health
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Dr. Iraklis I. Pipinos, MD, PhD

University of Nebraska at Medical Center
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Publications

Get in Touch

  4014 William Johnston Bldg.
143 Honors Way
Tallahassee, FL 32301
850.644.1829