Get to know Dr. Nagpal
Being a food and gut enthusiast, I firmly believe in the notions, “we are what we eat”, “all disease begins in the gut” and “let food be thy medicine”. Accordingly, my research interests span around understanding the host-associated microbiome and the dynamics of diet-gut-brain interface at the extremes of aging and in aging-associated metabolic and cognitive health. Specifically, our interdisciplinary lab aims at discovering novel signatures of gut dysbiosis in host metabolic diseases including obesity and type-2 diabetes and neuropsychiatric disorders including stress, anxiety and depression. Ultimately, we aim to explore how microbiome modulation with specific nutritional interventions including dietary elements, micronutrients, probiotics and prebiotics could ameliorate the pathology of these disorders.
- Postdoctoral training (Microbiome & host metabolism): Wake Forest School of Medicine, Winston-Salem, NC, USA
- Postdoctoral training (Probiotics & gut microbiota): Juntendo University School of Medicine, Tokyo, Japan
- PhD (Dairy Microbiology): National Dairy Research Institute, Karnal, India
- MS (Microbiology): Bundelkhand University, Jhansi, India
- BS (Life Sciences): DS College, Karnal, India
Publications and Other Scholarly Activities
Saccon TD*, Nagpal R*, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice. J Gerontol A Biol Sci Med Sci. 2021; glab002. doi: 10.1093/gerona/glab002.
Nagpal R, Neth BJ, Wang S, Mishra SP, Craft S, Yadav H. Gut mycobiome and its interaction with host diet, bacteriome and Alzheimer’s disease markers in subjects with mild cognitive impairment: a pilot study. EBioMedicine 2020; 59:102950.
Nagpal R, Mishra SP, Yadav H. Unique gut microbiome signatures depict diet- versus genetically-induced obesity in mice. Int J Mol Sci 2020; 21(10):E3434.
Young TM, Bray AS, Nagpal R, Caudell DL, Yadav H, Zafar MA. An animal model to study Klebsiella pneumoniae gastro-intestinal colonization and host-to-host transmission. Infect Immun 2020; 88(11):e00071-20.
Ahmadi S, Wang S, Nagpal R, Wang B, Jain S, Razazan A, Mishra SP, Zhu X, Wang Z, Kavanagh K, Yadav H. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating microbiota-taurine-tight junction axis. JCI Insight. 2020; 5(9):132055.
Ahmadi S, Razazan A, Nagpal R, Jain S, Wang B, Mishra SP, Wang S, Justice J, Ding J, McClain DA, Kritchevsky SB, Kitzman D, Yadav H. Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin axis. J Gerontol 2020; 75(7):e9-e21.
Wang S, Ahmadi S, Nagpal R, Jain S, Mishra SP, Kavanagh K, Zhu X, Wang Z, McClain DA, Kritchevsky SB, Kitzman DW, Yadav H. Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. GeroScience 2020; 42(1):333-352.
Nagpal R, Neth BJ, Wang S, Craft S, Yadav H. Modified Mediterranean-Ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. EBioMedicine 2019; 47:529-542.
Ahmadi S*, Nagpal R*, Wang R*, Gagliano J, Soleimanian-Zad S, Kitzman DW, Read R, Sheikh-Zeinoddin M, Yadav H. Prebiotics from acorn and sago prevent high-fat diet-induced insulin resistance via microbiome-gut-brain axis modulation. J Nutritional Biochem 2019; 67: 1-13.
Nagpal R, Wang S, Ahmadi S, Hayes J, Gagliano J, Subashchandrabose S, Kitzman D, Becton T, Read R, Yadav H. Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. 2018; Scientific Reports 8(1):12649.
Nagpal R, Shively SA, Register T, Craft S, Yadav H. Gut microbiome composition in non-human primates consuming a Mediterranean or Western diet. Front Nutr 2018; 5:28.
Nagpal R, Yamashiro Y. Gut microbiota composition in healthy Japanese infants and young adults born by C-section. Ann Nutr Metab 2018; 73(3):4–11.
Nagpal R, Kurakawa T, Tsuji H. et al. Dynamics of the gut Bifidobacterium microbiota during the first three years of life: a quantitative assessment. Scientific Reports 2017; 7(1): 10097.
Nagpal R, Tsuji H, Takahashi T, et al. Gut dysbiosis following C-section instigates higher colonization of α-toxigenic and enterotoxigenic C. perfringens in infants. Beneficial Microbes 2017; 8(3):353-365.
Nagpal R, Tsuji H, Takahashi T, et al. Sensitive quantitative analysis of the meconium bacterial microbiota in healthy term infants born vaginally or by cesarean section. Front Microbiol 2016; 7:1997.
Nagpal R, Ogata K, Tsuji H, Matsuda K, Takahashi T, Nomoto K, Nagata S, Yamashiro Y. Sensitive quantification of Clostridium perfringens in human feces by quantitative PCR targeting alpha-toxin and enterotoxin genes. BMC Microbiol 2015; 15: 219.
- Poster of Distinction recognition: European Society for Pediatric Gastroenterology, Hepatology & Nutrition (ESPGHAN); May 10-24, 2017; Prague, Czech Republic.
- Best Paper Award: European Society for Pediatric Gastroenterology, Hepatology & Nutrition (ESPGHAN); May 25-28, 2016; Athens, Greece.
- Young Investigator Award: Yakult India Microbiota and Probiotic Science Foundation; December 15-16, 2012; Bangaluru, India.
- Best Paper Award: Indian Dairy Association at 37th Dairy Industry Conference; Feb 7-9, 2009; Goa, India.
- Junior Researcher Scholarship: Asian federation of Societies of Lactic Acid Bacteria at 5th Asian Conference on Lactic Acid Bacteria; July 01-04, 2009; National University of Singapore, Singapore.
- Senior Research Fellowship (Doctoral): Indian Council of Agricultural Research, Government of India, 2004-2008.
- Editorial board member: Frontiers in Nutrition; Antibiotics; Recent Patents on Food, Nutrition and Agriculture